ALTERATIONS IN HISTOARCHITECTURE AND BIOCHEMICAL MARKERS OF LIVER AND KIDNEY FUNCTIONS ON SUB-ACUTE EXPOSURE OF IVERMECTIN IN ALBINO RATS

Abstract

The present study was performed to evaluate alterations in histoarchitecture and biochemical markers of liver and kidney function on sub-acute exposure of Ivermectin in albino rats. Albino rats weighing 180-200 gm were treated with Ivermectin orally and divided into two groups, each group consistedof six rats. The rats of group I served as control. However, rats of group II were treated with ivermectin @ 5 mg/kg b.wt.Blood samples were collected on day 28 of experiment with the help of capillary tube for estimation of biochemical parameters andliver and kidney tissues samples were collected for histopathological examination. Ivermectin altered the functions of liver and kidney as indicated by the alterations in the biochemical markers and histopathological examinations of liver and kidney.Ivermectin significantly enhanced the concentration of biochemical markers of liver function viz. AST, ALT, ALP and Bilirubin as compared to control. The concentration of biochemical markers of kidney function viz. BUN and creatinine were significantly enhanced after ivermectin administration, as compared to control.Hepatomegaly with congestion and loss of demarcation between cortex and medulla in kidney were observed. Histopathologically, hydropic degeneration, vacuolation and congestion of hepatic tissues and marked congestion along with haemorrhages were found on histoarchitecture study of kidney tissue.Ivermectin have ability to alter the histoarchitecture and biochemical markers of liver and kidney in albino rats after the sub-acute exposure for 28 days.