CLINICOPHYSIOLOGICAL AND HAEMODYNAMIC EFFECTS OF DEXMEDETOMIDINE, XYLAZINE AND BUTORPHANOL AS PREANAESTHETIC AGENT IN CONJUNCTION WITH TILETAMINE-ZOLAZEPAM IN DOGS

Abstract

The study was designed in 18 dogs presented in the VCC for surgical interventions to evaluate the best suitable anaesthetic protocol and to determine the various clinicophysiological and haemodynamicaleteration before, during and after the anaesthesia. Animals were divided into three groups of six animal each and in all the groupstiletamine-zolazepam @6.5mg/kg b.wt. was administered as induction and maintainanece anaesthesia. As preanaesthetic agent atropine sulphate @0.04 mg/kg b,wt. was administered in all groups. However in group I dexmedetomidine was administered @ 0.02 mg/kg b.wt. I/V, in group II xylazine @ 1 mg/kg bwt. and in group III butorphanol @ 0.2 mg/kg bwt. was administered as premedication agents. Heart rate significantly increased after administration of tiletamine-zolazepam in all three groups, however significant decrease in respiration rate was observed in group I. the gradual decrease in the rectal temperature was observed in all three groups. A significant decrease in the spo2 value was observed in group I however in group II and III spo2 was in between 96% and 97%. MAP increased significantly in group I and II however a gradual decrease was observed in group III. All the clinico-physiological and haemodynamic parameter came near to itspreanaesthetic value at the end of the observation period.